骨质疏松与眼部疾病相关性的研究进展OA
Research progress on the association between osteoporosis and ocular diseases
在老年人群中,骨质疏松症(OP)常与多种年龄相关性眼病同时存在.两者不仅在组织结构上有共病基础,在病理生理机制和药物治疗方面也存在复杂关联.本文从巩膜和骨骼共有的Ⅰ型胶原同源性入手,系统梳理了衰老、炎症、氧化应激及激素调控等共同机制,分析了抗OP药物对眼部可能产生的利与弊,并提出未来的重点研究方向,有助于临床医生提高对骨-眼共病的认识.
Osteoporosis frequently coexists with various age-related ocular diseases in elderly populations.These conditions not only share common anatomical foundations but are also closely interconnected through complex pathophysio-logical mechanisms and pharmacological interactions.Starting from the homology of type Ⅰ collagen shared by the sclera and bone tissue,this review systematically summarizes the common mechanisms underlying osteoporosis and ocular disea-ses,including aging,inflammation,oxidative stress,and hormonal regulation.In addition,the potential beneficial and adverse ocular effects of anti-osteoporosis medications are discussed.Finally,future research priorities are proposed to improve clinicians' understanding of bone-eye comorbidities and to promote interdisciplinary management strategies.
常岩;李佳
武警青海总队医院眼科(青海西宁 810000)中国人民解放军南部战区总医院内分泌科(广东 广州 510080)
医药卫生
骨质疏松巩膜炎症氧化应激药物不良反应
osteoporosissclerainflammationoxidative stressadverse drug reactions
《广东医学》 2026 (7)
973-977,5
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