核转录因子κB、多肿瘤抑制基因与宫颈癌临床特征及放疗敏感性的关系OA

Objective:To investigate the relationship between nuclear factor-kappa B(NF-κB),multiple tumor suppressor gene(P16)and clinical features of cervical cancer as well as sensitivity to radiotherapy.Methods:Retrospective collection of clinical data from 119 patients with cervical cancer.All patients were tested for the positive expression of NF-κB and P16 in cervical cancer cells.The relationship between their expression and clinical features as well as sensitivity to radiotherapy was analyzed.Results:Among the 119 specimens,88(73.95%)were positive for NF-κB and 97(81.51%)were positive for P16.The positive expression rates of NF-κB and P16 showed significant differences between patients with varying degrees of differentiation and patients with/without lymph node metastasis(P<0.05).Spearman correlation analysis revealed that the positive expression rate of NF-κB was positively correlated with the degree of differentiation and lymph node metastasis(P<0.05),whereas the positive expression rate of P16 was negatively correlated with these clinical features(P<0.05).Univariate and multivariate Logistic regression analyses indicated that lymph node metastasis and NF-κB positivity were independent risk factors for insensitivity to radiotherapy,whereas P16 positivity was an independent protective factor against(P<0.05).Conclusion:NF-κB and P16 are closely related to the degree of differentiation and lymph node metastasis in cervical cancer.The positive expression of NF-κB and the positive expression of P16 are influencing factors for insensitivity to radiotherapy.