人群镉和铅暴露与慢性肾脏病发病风险的meta分析OA

OBJECTIVE:To investigate associations between metal exposure(cadmium and lead)and risk of chronic kidney disease(CKD)in populations through a meta-analysis.METHODS:A systematic search was conducted using PubMed,Web of Science,The Cochrane Library,SinoMed,CNKI and Wanfang databases.Meta-analysis,sensitivity analysis,and publication bias assessment were performed using Stata 15.0 software.RESULTS:A total of 24 studies were included,comprising 21 studies on associations between cadmium exposure and CKD and 16 studies on lead exposure.Among them,13 were reports that took cadmium and lead exposure as exposure variables.Our meta-analysis demonstrated that cadmium exposure in populations significantly increased risk of CKD[OR=1.54;95%CI(1.33,1.79)],with moderate heterogeneity observed among studies(I2=76.5%,P<0.05).Lead exposure was positively associated with CKD risk[OR=1.46;95%CI(1.21,1.76)],with significant heterogeneity among studies(I2=88.0%,P<0.05).Sensitivity analysis confirmed robustness of the findings.No significant publication bias was detected in the included studies.CONCLUSION:Cadmium and lead exposure in populations was associated with increased risk of CKD,indicating that metal exposure is a significant risk factor for CKD.