哺乳动物卵母细胞玻璃化冷冻中抗氧化剂对活性氧的调控作用研究进展OA

Excessive accumulation of reactive oxygen species(ROS)during the vitrification of mammalian oocytes induces oxidative stress,severely impairing the structural integrity and functional competence of the oocytes.This oxidative damage has become a major bottleneck limiting post-thaw survival rates and developmental potential.Antioxidants can effectively alleviate oxidative injury by scavenging excessive ROS and enhancing the structure and function of endogenous antioxidant systems,thereby improving the efficiency of oocyte cryopreservation.This review article systematically summarizes the sources and mechanisms of ROS-induced damage during oocyte vitrification,including lipid peroxidation,protein misfolding,mitochondrial dysfunction,and activation of apoptotic signaling pathways.Furthermore,it explores the mechanisms by which different types of antioxidants regulate ROS and evaluates their efficacy in the vitrification of oocytes.The aim is to provide new insights for the development of more effective cryoprotective strategies.