外消旋聚乳酸可吸收隔离膜的静电纺丝工艺及性能研究OA

To explore the potential application of poly(D,L-lactic acid)(PDLLA)in tissue repair,we used PDLLA as the sub-strate material and prepared the precursor solution by mixing chloroform and N,N-dimethylformamide(CF/DMF)as the solvent.PDL-LA absorbable barrier membranes were fabricated via the electrospinning process.The membrane exhibited a most probable pore size of 1.08 μm and porosity of 64.6%,which could provide appropriate channels for the transport of nutrients and excretion of metabolites.Mechanical test results showed that the membrane had a tensile strength of up to 7.09 MPa,elongation at break of 129%,and tearing force of 4.39 N,which could meet the mechanical requirements for tissue barrier membranes.In vitro degradation experiments con-firmed that the PDLLA membrane could maintain stable mechanical properties within a 3-month degradation period,ensuring the sus-tained and effective performance of the tissue isolation function.This study can provide a basis for the clinical application of PDLLA ab-sorbable isolation membranes.