Hippo信号通路在心力衰竭中的差异性调控及其研究进展OA

Heart failure is a major global health challenge,and its prevalence continues to rise.The Hippo pathway is a key regulator of cell proliferation,apoptosis,mechanotransduction,and tissue homeostasis,and it plays a critical role in the development and progression of heart failure.This review systematically summarizes the regulatory mechanisms of the core components of the Hippo pathway,with emphasis on its stage-specific alterations across different heart failure subtypes and its cell-specific roles in various car-diac cell populations.It further describes how the Hippo pathway is deeply involved in multiple key pathological processes of heart fail-ure through its effects on cardiomyocyte metabolism and proliferation,cardiac fibroblast differentiation,endothelial function,and the differential regulation of macrophage function.In addition,this review summarizes a range of Hippo pathway modulators,highlighting their differences from conventional heart failure therapies as well as their potential synergistic effects.Overall,this article outlines the specific molecular mechanisms of the Hippo pathway in heart failure and offers a new perspective for the treatment of this disease.