2012-2024年重庆市急性心肌梗死死亡疾病负担研究OA

Objective To analyze the trends in mortality and disease burden of acute myocardial infarction(AMI)in Chongqing from 2012 to 2024,and to provide recommendations for AMI prevention and control.Methods AMI death cases from 2012 to 2024 were obtained from the Chongqing Cause-of-Death Surveillance System.SPSS 25.0 and Excel 2010 were used to calculate mortality,age-standardized mortality,age-specific mortality,years of life lost(YLL)rate,and average years of life lost(AYLL).The chisquare test was used for comparisons between different sexes and regions.Joinpoint re-gression was used to calculate the annual percentage change(APC)and average annual percentage change(AAPC)to ana-lyze trends.Results In 2012,the crude mortality and age-standardized mortality of AMI in Chongqing were 19.54/100,000 and 11.46/100,000,respectively;in 2024,they were 36.46/100,000 and 14.08/100,000,respectively.The crude mortali-ty increased at an average annual rate of 4.018%(P=0.002),while the age-standardized mortality showed no significant change(P=0.747).Segmented analysis showed that the age-standardized mortality increased at an average annual rate of 22.884%from 2012 to 2015(P<0.001)and then decreased at an average annual rate of 3.708%from 2015 to 2024(P=0.002).From 2018 to 2024,the mortality was higher in males than in females(P<0.05).The age-standardized mortality in both males and females showed an initial increase followed by a decrease,with 2015 as the turning point,and the trends were statistically significant(P<0.05).From 2012 to 2013,the mortality in urban areas was higher than that in rural are-as,while from 2015 to 2024,the mortality in rural areas was higher than that in urban areas(P<0.05).The crude mortal-ity and age-standardized mortality in urban areas decreased at average annual rates of 5.401%and 7.697%,respectively(P<0.05).In rural areas,the crude mortality increased at an average annual rate of 6.822%(P<0.001),while the age-standardized mortality showed no significant change(P=0.118).The YLL rate due to AMI in Chongqing increased from 3.70‰ in 2012 to 6.24‰ in 2024,with an AAPC of 3.346%(P=0.023).The AYLL due to AMI decreased from 18.95 years in 2012 to 16.99 years in 2024,with an AAPC of-0.740%(P=0.002).The top two places of death for AMI pa-tients were at home and in medical institutions,accounting for over 90%of the total,with about 70%and 20%dying at home and in medical institutions,respectively.Conclusion The crude mortality and YLL rate of AMI in Chongqing showed an increasing trend from 2012 to 2024.Males and rural residents are the key populations for AMI prevention and control.Comprehensive prevention and treatment of AMI should be further strengthened,and the AMI treatment system should be improved.