牙周炎通过DAGK调控ERK1/2-NF-κB信号通路加重心肌梗死的机制研究OA

Objective To investigate the causal relationship between periodontitis and myocardial infarction and to elucidate the underlying molecular mechanisms.Methods A two-sample Mendelian randomization analysis was employed to assess the causal association between periodontitis and myocardial infarction,combined with bioinformatics analysis to screen for potential therapeutic tar-gets.In vivo validation was conducted using established animal models,utilizing techniques such as micro-CT,histological staining,immunofluorescence staining,echocardiography,and electrocardiography.Results The Mendelian randomization analysis demonstra-ted a significant positive correlation between periodontitis and the risk of myocardial infarction.Mechanistic investigations revealed that periodontitis exacerbates post-myocardial infarction pathological injury via the activation of the diacylglycerol kinase-mediated extracel-lular signal-regulated kinase1/2-nuclear factor κB(ERK1/2-NF-κB)signaling pathway.Conclusion Periodontitis serves as a risk factor for myocardial infarction,with mechanisms potentially involving the diacylglycerol kinase-regulated ERK1/2-NF-κB signaling pathway.These findings provide effective strategies for improving the prognosis of myocardial infarction patients with comorbid peri-odontitis and mitigating adverse ventricular remodeling.