焦虑在老年肺癌患者认知功能与肌少症间的中介作用OA

Objective To investigate the mediation role of anxiety in the relationship between cognitive function and sar-copenia in elderly lung cancer patients,providing a theoretical basis for clinical interventions in this population.Methods A retro-spective study was conducted involving 258 elderly lung cancer patients from Karamay Central Hospital from October 2022 to January 2025.Participants were assessed using a demographic questionnaire,the Mini-Mental State Examination(MMSE),and the General-ized Anxiety Disorder-7(GAD-7)scale.Data analysis employed Spearman's rank correlation analysis and the PROCESS procedure to evaluate mediation effects.Results The prevalence of sarcopenia among elderly lung cancer patients was 43.8%.Spearman's correla-tion coefficient revealed a significant negative correlation between cognitive function and anxiety(r=-0.869,P<0.001),and a signif-icant positive correlation between anxiety and sarcopenia(r=0.560,P<0.001).Mediation effect analysis revealed no direct associa-tion between cognitive function and sarcopenia(B=-0.053,P=0.271).Anxiety exerted a significant mediation effect between cogni-tive function and sarcopenia(indirect effect a×b=-0.176,95%CI:-0.277 to-0.095;Here,a×b represents the indirect effect val-ue,reflecting the strength of cognitive function's influence on sarcopenia through anxiety).Conclusion Anxiety plays a significant mediation role between cognitive function and sarcopenia in elderly lung cancer patients.Clinical management should prioritize mental health interventions to enhance overall health outcomes in this population.