老年原发性高血压患者内皮祖细胞与动脉硬化的关系OA
The relationship between endothelial progenitor cells and arteriosclerosis in elderly patients with essential hypertension
目的 探讨老年原发性高血压患者外周血内皮祖细胞(EPCs)与动脉硬化的相关性.方法 选取2024 年7 月—2025 年7 月就诊于内蒙古自治区人民医院健康管理中心及老年医学科的60 岁及以上确诊为原发性高血压的老年患者340 例作为研究对象,按 EPCs 水平四分位数将患者分为 Q1 组～Q4组,分别为85、85、83、87 例;采用多因素线性回归模型探讨不同因素与动脉硬化的线性关系,依据是否有吸烟史、饮酒史、糖尿病史及体质量指数(BMI)水平(BMI≥28 kg/m2 或 BMI<28 kg/m2)进行亚组分层以验证该关联的稳健性,同时绘制 ROC 曲线评估 EPCs 对老年原发性高血压患者发生动脉硬化的预测价值.结果 老年原发性高血压患者中,不同水平 EPCs 的人群年龄、性别、吸烟史、饮酒史、糖尿病史、收缩压(SBP)、舒张压(DBP)、臂踝脉搏波传导速度(baPWV)、心率(HR)、平均动脉压(MAP)、超敏 C 反应蛋白(hs-CRP)、甘油三酯(TG)、总胆固醇(TC)、空腹血糖(FBS)之间差异均具有统计学意义(P<0.05).多因素线性回归分析显示,糖尿病史、SBP 为影响老年原发性高血压患者动脉硬化程度的独立危险因素,EPCs 为其保护因素.亚组分析表明,EPCs 与 baPWV 呈负相关(P<0.05).EPCs 预测老年原发性高血压患者发生动脉硬化的 ROC 曲线下面积为0.883,相较于 SBP 显示出较高的预测价值.结论 外周血循环 CD34+CD309+双阳性 EPCs 与 baPWV 呈负相关,可以作为预测老年原发性高血压患者动脉硬化的一个生物学指标.
Objective To investigate the correlation between peripheral blood endothelial progenitor cells(EPCs)and arte-riosclerosis in elderly patients with essential hypertension.Methods A total of 340 elderly patients aged 60 years and above diagnosed with essential hypertension,who visited the Health Management Center and Department of Geriatrics at Inner Mongolia Autonomous Re-gion People's Hospital from July 2024 to July 2025,were enrolled as study subjects.Patients were stratified into four groups(Q1-Q4)based on EPCs quartile levels,comprising 85,85,83,and 87 cases,respectively;multivariable linear regression models were con-structed to investigate the linear relationships between various factors and arteriosclerosis/arterial stiffness.The robustness of the associ-ation was further assessed through subgroup analyses stratified by history of smoking,alcohol consumption,diabetes,and body mass index(BMI)levels(BMI≥28 kg/m2 vs.<28 kg/m2).Meanwhile,receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of EPCs for arteriosclerosis in elderly patients with essential hypertension.Results Among elderly pa-tients with essential hypertension,there were statistically significant differences(P<0.05)in age,gender,smoking history,drinking history,diabetes history,systolic blood pressure(SBP),diastolic blood pressure(DBP),brachial-ankle pulse wave velocity(baP-WV),heart rate(HR),mean arterial pressure(MAP),high-sensitivity C-reactive protein(hs-CRP),triglycerides(TG),total cholesterol(TC),and fasting blood glucose(FBG)across groups with different levels of endothelial progenitor cells(EPCs).Multi-variate linear regression analysis showed that history of diabetes and SBP were independent risk factors for the degree of arteriosclerosis in elderly patients with essential hypertension,while EPCs were a protective factor.Subgroup analysis indicated that EPCs were nega-tively correlated with baPWV(P<0.05).The area under the ROC curve for EPCs in predicting arteriosclerosis in elderly patients with essential hypertension was 0.883,demonstrating a higher predictive value compared to SBP.Conclusion Circulating CD34+CD309+double-positive EPCs in peripheral blood are negatively correlated with baPWV and may serve as a potential biomarker for predicting arterial stiffness in elderly patients with essential hypertension.
李卫红;邬倩;李树斌;孙于欣;李红;格日乐其其格;邬真力
内蒙古科技大学包头医学院,内蒙古 包头 014000内蒙古自治区人民医院老年医学中心,内蒙古 呼和浩特 010017内蒙古自治区人民医院老年医学中心,内蒙古 呼和浩特 010017内蒙古医科大学,内蒙古 呼和浩特 010059内蒙古医科大学,内蒙古 呼和浩特 010059内蒙古科技大学包头医学院,内蒙古 包头 014000内蒙古自治区人民医院老年医学中心,内蒙古 呼和浩特 010017
原发性高血压内皮祖细胞动脉硬化臂踝脉搏波传导速度
Essential hypertensionEndothelial progenitor cellsArteriosclerosisBrachial-ankle pulse wave velocity
《国际老年医学杂志》 2026 (4)
404-410,7
国家自然科学基金资助项目(82360285)
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