Research application of immunomodulatory nanomaterials in Alzheimer''s disease vaccine developmentOA
Alzheimer''s disease(AD)is a common neurodegenerative disorder,and there is currently no effective treatment,which brings a significant burden to patients and their families.In recent years,immunomodulatory nanomaterials have shown great potential in the development of AD vaccines due to their excellent biocompatibility and targeting ability.Existing studies indicate that immunomodulatory nanomaterials can effectively improve the delivery mechanism and immune response of vaccines,promote the presentation of specific antigens,and regulate the body''s immune response,thereby playing a crucial role in the prevention and treatment of AD.This review comprehensively analyzes the latest research progress of immunomodulatory nanomaterials in the development of AD vaccines,explores their design principles,delivery mechanisms,immune modulation effects,and relevant preclinical research results.Furthermore,challenges in current research and future development directions are discussed,aiming to provide reference for research in this field.
Jiejie Guo;Ting Zhang;Yexuzi Li;Chen Peng;Mengjia Li;Qian Yan;Bo Shao
Neurosurgery Department,The Affiliated Wenling Hospital of Taizhou University(The First People’s Hospital of Wenling),Taizhou 317500,China Department of Clinical Laboratory,The Affiliated Wenling Hospital of Taizhou University(The First People’s Hospital of Wenling),Taizhou 317500,China Department of Infection Prevention and Control,The Affiliated Wenling Hospital of Taizhou University(The First People’s Hospital of Wenling),Taizhou 317500,ChinaDepartment of Clinical Laboratory,The Affiliated Wenling Hospital of Taizhou University(The First People’s Hospital of Wenling),Taizhou 317500,ChinaDepartment of Infection Prevention and Control,The Affiliated Wenling Hospital of Taizhou University(The First People’s Hospital of Wenling),Taizhou 317500,ChinaNutrition Department,The Affiliated Wenling Hospital of Taizhou University(The First People’s Hospital of Wenling),Taizhou 317500,ChinaDepartment of Clinical Laboratory,The Affiliated Wenling Hospital of Taizhou University(The First People’s Hospital of Wenling),Taizhou 317500,ChinaDepartment of Clinical Laboratory,Wenling Hospital of Traditional Chinese Medicine,Taizhou 317500,ChinaNeurosurgery Department,The Affiliated Wenling Hospital of Taizhou University(The First People’s Hospital of Wenling),Taizhou 317500,China
通用工业技术
Immunomodulatory nanomaterialsAlzheimer''s diseaseVaccine developmentTargeted deliveryNeuroinflammation
《Nano Biomedicine & Engineering》 2026 (1)
P.104-114,11
supported by the Medical Health Science and Technology Project of Zhejiang Provincial Health Commission(2025KY1882,2025KY1887,2023KY1346)Zhejiang Province Disease Prevention and Control Science and Technology Program(2025JK320)the Wenling Science and Technology Project(2025S00081,2024S00264,2022S00019,2024S00008)
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