Atomically engineered nanozymes(AEN):Revolutionizing catalytic immunemodulation for biomedical advancesOA
Immunotherapy holds enormous potential to improve treatment results,however,the low response rate remains a significant challenge.Conventional immunomodulatory methods often cause off-target effects,limited specificity,and systemic toxicity.To address these issues,new catalytic nanomaterials have emerged as a promising approach to boost catalytic immunotherapy by steering the immune response through specific biochemical reactions.Atomically engineered nanozymes(AENs)are an advanced field in biomedical research,combining precise nanotechnology with catalytic functions to enhance immune regulation.This review examines the design,synthesis,and application of AENs as multifunctional tools for progressing therapies in immunotherapy and disease diagnostics.AENs leverage atomic-level control to mimic natural enzyme functions,improving stability,tunability,and specificity for accurate immune response control.In this review,we highlight their mechanisms,including their ability to modulate reactive oxygen species(ROS),activate immune signaling pathways,and overcome traditional therapy limitations.Finally,we discuss challenges related to scalability and clinical translation,along with future directions for integrating AENs into personalized medicine and immune-engineering strategies.
Kehui Yuan;Jun Zhang;Yan Wang;Yang Yang;Sumaira Hanif;Guoping Chen;Saud Asif Ahmed;Chenchen Li;Yanli Wang;Pir Muhammad
The First Affiliated Hospital of Hainan Medical University,Hainan Medical University,Haikou 571199,China Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education,International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province,School of Pharmacy,Hainan Academy of Medical Sciences,Hainan Medical University,Haikou,Hainan 571199,ChinaNHC Key Laboratory of Tropical Disease Control,School of Life Sciences and Medical Technology,Hainan Medical University,Haikou,Hainan 571199,ChinaEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education,International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province,School of Pharmacy,Hainan Academy of Medical Sciences,Hainan Medical University,Haikou,Hainan 571199,ChinaEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education,International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province,School of Pharmacy,Hainan Academy of Medical Sciences,Hainan Medical University,Haikou,Hainan 571199,ChinaNHC Key Laboratory of Tropical Disease Control,School of Life Sciences and Medical Technology,Hainan Medical University,Haikou,Hainan 571199,ChinaThe First Affiliated Hospital of Hainan Medical University,Hainan Medical University,Haikou 571199,China Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education,International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province,School of Pharmacy,Hainan Academy of Medical Sciences,Hainan Medical University,Haikou,Hainan 571199,ChinaEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education,International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province,School of Pharmacy,Hainan Academy of Medical Sciences,Hainan Medical University,Haikou,Hainan 571199,ChinaEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education,International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province,School of Pharmacy,Hainan Academy of Medical Sciences,Hainan Medical University,Haikou,Hainan 571199,ChinaEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education,International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province,School of Pharmacy,Hainan Academy of Medical Sciences,Hainan Medical University,Haikou,Hainan 571199,ChinaEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education,International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province,School of Pharmacy,Hainan Academy of Medical Sciences,Hainan Medical University,Haikou,Hainan 571199,China
通用工业技术
atomically engineered nanozymesimmunotherapycatalytic materialimmunomodulationreactive oxygen speciespersonalized medicine
《Nano Biomedicine & Engineering》 2026 (1)
P.35-57,23
the financial support from the National Natural Science Foundation of China(82325030 and 52371250)Hainan Provincial Natural Science Foundation High-Level Talent Project(824RC512)HNMU-Research Start-up Funding(RZ2300005998)the National Key Research Development Program of China(2022YFC2305000)Science and Technology special fund of Hainan Province(ZDYF2024SHFZ080)
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