Nanozymes in immune regulation:Applications and progressOA
The immune system is essential for maintaining physiological balance,defending against pathogens,and eliminating abnormal cells.Immune dysregulation-manifesting as either suppression or hyperactivation-plays a central role in the pathogenesis of diseases such as cancer,rheumatoid arthritis,and chronic inflammatory disorders.As a novel class of catalytic nanomaterials,nanozymes possess enzyme-mimicking activities and exhibit high stability,biocompatibility,and tunable functionalities,enabling them to serve as versatile tools in immunomodulation.This review highlights the dual immunoregulatory capabilities of nanozymes and their context-dependent therapeutic applications,including promoting antitumor immunity,restoring immune homeostasis in autoimmune diseases,and attenuating pathological inflammation.We systematically discuss the mechanisms by which nanozymes modulate immune responses,reshape immune microenvironments,and influence key signaling pathways.These insights aim to facilitate the rational design of next-generation nanozymebased immunotherapeutics.
Yue Zhao;Tianjiao Ji;Fanggui Ye;Zhuoran Wang;Xiyun Yan
State Key Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China University of Chinese Academy of Sciences,Beijing 101408,ChinaUniversity of Chinese Academy of Sciences,Beijing 101408,China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology,Chinese Academy of Sciences,Beijing 100190,ChinaSchool of Chemistry and Pharmaceutical Sciences,Guangxi Normal University,Guilin,Guangxi 541004,ChinaState Key Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,ChinaState Key Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China University of Chinese Academy of Sciences,Beijing 101408,China Nanozyme Laboratory in Zhongyuan,Henan Academy of Innovations in Medical Science,Zhengzhou,Henan 451163,China
医药卫生
NanozymeImmunotherapyCancerRheumatoid arthritisInflammatory bowel disease
《Nano Biomedicine & Engineering》 2026 (1)
P.7-20,14
financially supported by the National Natural Science Foundation of China Joint Fund for Regional Innovation Development Project(No.U23A20522,U23A20686)National Natural Science Foundation of China(No.32301163,82122037)the National Key Research and Development Program of China(2021YFA1201102,2019YFA0709204)
评论