Cellular Senescence in the Cardiovascular System:Molecular Mechanisms,Pathophysiology,and Senotherapeutic InterventionsOA
Cellular senescence and the Senescence-Associated Secretory Phenotype(SASP)play both physiological and pathological roles in the cardiovascular system.While transient senescence aids regeneration,chronic accumulation of senescent cells promotes endothelial dysfunction,arterial stiffening,and maladaptive cardiac remodeling.This review elucidates the pivotal role of the immune system in senescent cell clearance and explores how immunosenescence drives systemic low-grade inflammation.Significant emphasis is placed on emerging pharmacological strategies,specifically senolytics and senomorphics,assessing their capacity to restore cardiac function and attenuate atherosclerosis.Additionally,the utility of molecular biomarkers and diverse in vitro and in vivo models is analyzed in the context of therapeutic efficacy.Ultimately,this article asserts that a comprehensive understanding of senescent-immune interactions is fundamental to the development of targeted,personalized interventions for age-related cardiovascular pathologies.
Beata Franczyk;Anna Bajer;Anna Bulicz;Mikołaj Grabarczyk;Paulina Jakubowska;Katarzyna Krawiranda;Natalia Kustosik;Przemysław Kuzar;Klaudia Leszto;Maja Mejza;Weronika Mstowska;Jacek Rysz;Ewelina Młynarska
Department of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,PolandDepartment of Nephrology,Hypertension and Internal Medicine,Medical University of Lodz,Lodz,PolandDepartment of Nephrocardiology,Medical University of Lodz,Lodz,Poland
医药卫生
Cellular senescencecardiovascular agingsenolyticssenomorphicscardiovascular systemheart failureatherosclerosisendothelial dysfunction
《BIOCELL》 2026 (7)
P.1-40,40
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