Highly divergent virome in wild rodents of Xinjiang,China:Implications for rodent origin of porcine reproductive and respiratory syndrome virus 1OA
Rodents play a pivotal role in the maintenance and transmission of zoonotic viruses.The Yili River Valley,one of the most biodiverse regions in Xinjiang,functions as a critical biogeographic corridor linking China with Central and Western Asia,and historically with Europe via the ancient Silk Road.Despite its significance,the viral landscape of this region remains largely unexplored.To elucidate the virological landscape of this understudied region,meta-transcriptomic sequencing was conducted on wild rodent samples collected between 2020 and 2023,encompassing multiple host species and tissue types(liver,lung,spleen,and intestine).Analysis identified 18vertebrate-associated viral families,including several of known zoonotic or evolutionary relevance,such as Arteriviridae,Coronaviridae,Flaviviridae,Hantaviridae,Hepeviridae,Hepadnaviridae,and Picornaviridae.Remarkably,over 80% of the detected viruses represented putative novel species,highlighting the vast and previously undocumented viral diversity harbored by rodents in this region.Viral community composition exhibited clear hostand tissue-specific patterns.Critically,novel rodent-derived arteriviruses(Rt Arte Vs)in Microtus obscurus were identified,exhibiting approximately 86% nucleotide identity with porcine reproductive and respiratory syndrome virus 1(PRRSV1).Additionally,phylogenetic and recombination analyses support the hypothesis that PRRSV1 emerged through ancestral recombination among divergent RtArteVs,implicating rodents as the likely origin of this economically significant swine pathogen.These findings expand current understanding of rodent viromes in an important biodiversity hotspot,revealing a substantial yet largely uncharted viral diversity.Furthermore,this study underscores the critical need for continued surveillance of viral groups with potential for viral spillover to humans and domestic animals,including Arteriviridae,Flaviviridae,Hantaviridae,Hepeviridae,and Hepadnaviridae.
Le Cao;Ying-Ying Ma;Guo-Wu Zhang;Jun Li;Wen-Jing Qi;Chuan-Chuan Wu;Meng-Xiao Tian;Yao Zhang;Zhuang-Zhi Zhang;Ming-Zhi Yan;Malike Aizezi;Yan-Peng Li;Chi-Yu Zhang;Wen-Bao Zhang
Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaShanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaState Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,ChinaState Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,ChinaState Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,ChinaCollege of Basic Medical Sciences,Xinjiang Medical University,Urumqi,Xinjiang 830054,ChinaCollege of Basic Medical Sciences,Xinjiang Medical University,Urumqi,Xinjiang 830054,ChinaCollege of Basic Medical Sciences,Xinjiang Medical University,Urumqi,Xinjiang 830054,ChinaVeterinary Research Institute,Xinjiang Academy of Animal Sciences,Urumqi,Xinjiang 830000,ChinaState Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,ChinaXinjiang Uyghur Autonomous Region Center for Animal Disease Control and Prevention,Urumqi,Xinjiang 830011,ChinaShanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaShanghai Public Health Clinical Center,Fudan University,Shanghai 201508,ChinaState Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,China College of Basic Medical Sciences,Xinjiang Medical University,Urumqi,Xinjiang 830054,China
农业科技
ViromeRodentZoonotic transmissionVirus evolution
《Zoological Research》 2026 (1)
P.72-87,16
supported by the Research on Genetic Evolution Characteristics and Key Techniques for Tracing of Highly Pathogenic Viruses,National Key Research and Development Program(2023YFC2605602)Xinjiang Science and Technology Department’s“Tianshan Talents”Training Program-Science and Technology Innovation Team Project(2023TSYCTD0017)National Natural Science Foundation of China(32370153)。
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