Research progress on regulation of tumor microbiota by Chinese herbal medicines targeting matrix stiffnessOA
Tumor occurrence and development are co-regulated by extracellular matrix(ECM)stiffness and the intratumoral microbiota.This paper first systematically summarizes how matrix stiffness affects the composition and function of the intratumoral microbiota.It then analyzes the regulatory roles of microbiota alterations in tumor occurrence and progression.Furthermore,it summarizes the mechanisms by which bacteria drive tumor progression,including inflammatory activation,metabolic reprogramming,and regulation of oncogenic signaling pathways.On this basis,the anti-tumor mechanisms of Chinese herbal medicines targeting the multi-dimensional regulatory network of the“matrix stiffness-bacteria-tumor”axis are discussed.This review provides an important theoretical basis for understanding bacterium-tumor interactions and for developing Chinese herbal medicine-based therapeutic strategies targeting this axis.
Zhao Liu;Wen-Jing Zhang;Jia-Hua He;Ting-Ting Wan;Yang-Yang Bian;Zhuo Li;Jing Wang;Yu-Ting Zhang;Xiao-Ye Liu
College of Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,ChinaBeijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,ChinaCollege of Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,China Beijing Key Laboratory of Traditional Chinese Veterinary Medicine,Beijing University of Agriculture,Beijing 10026,China
医药卫生
extracellular matrix stiffnesstumorbacteriaChinese herbal medicine
《Traditional Medicine Research》 2026 (11)
P.51-65,15
supported by Preliminary Project of Beijing University of Agriculture(No.KYCB-2026001).
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