The dual function of mitophagy in ferroptosisOA
Ferroptosis is a new form of cell death driven by iron-dependent lipid peroxidation.Thus,it is closely related to the lipid and iron metabolism.Accumulating evidence has suggested mitochondria,the center of cell metabolism,are important regulators of ferroptosis.This is not surprising as mitochondria are also the center for lipid metabolism and iron metabolism,as well as redox balance.As the essential way of mitochondrial quality control,mitophagy may alleviate ferroptosis.On the other hand,the digestion of iron-rich mitochondria may provide ample sources for the activation of ferroptosis.This review describes these new findings about the interplay of mitophagy and ferroptosis and demonstrates the dual role of mitophagy in ferroptosis.
Xiaoxuan Zeng;Xushan Ma;Yueping Bai;Jiaqi Li;Fan Yu
State Key Laboratory of Medicinal Chemical Biology,College of Pharmacy,Key Laboratory of Molecular Drug Research and KLMDASR of Tianjin,Nankai University,Tianjin 300350,ChinaState Key Laboratory of Medicinal Chemical Biology,College of Pharmacy,Key Laboratory of Molecular Drug Research and KLMDASR of Tianjin,Nankai University,Tianjin 300350,ChinaState Key Laboratory of Medicinal Chemical Biology,College of Pharmacy,Key Laboratory of Molecular Drug Research and KLMDASR of Tianjin,Nankai University,Tianjin 300350,China School of Health and Life Sciences,Qingdao Central Hospital,University of Health and Rehabilitation Sciences,Qingdao 266113,Shandong,ChinaState Key Laboratory of Medicinal Chemical Biology,College of Pharmacy,Key Laboratory of Molecular Drug Research and KLMDASR of Tianjin,Nankai University,Tianjin 300350,ChinaState Key Laboratory of Medicinal Chemical Biology,College of Pharmacy,Key Laboratory of Molecular Drug Research and KLMDASR of Tianjin,Nankai University,Tianjin 300350,China School of Health and Life Sciences,Qingdao Central Hospital,University of Health and Rehabilitation Sciences,Qingdao 266113,Shandong,China
医药卫生
MitophagyFerroptosisROSIron
《Biophysics Reports》 2026 (2)
P.116-125,10
supported by a grant from the National Natural Science Foundation of China(32100549)to Fan Yu。
评论