Differences of the lamina cribrosa between primary open angle glaucoma and non-pathologic high myopiaOA
Primary open angle glaucoma(POAG)is a chronic,blinding ocular disorder characterized by progressive degeneration of retinal ganglion cells(RGCs).Its incidence and prevalence of blindness continue to increase with global population aging.Non-pathologic high myopia(HM)has been established as an independent risk factor for POAG,and the two conditions share similar structural changes in the lamina cribrosa(LC)during the early phase of optic nerve injury.This review summarizes the common and distinct pathological alterations of LC in POAG and HM,with the aim of clarifying its central role in the initiation and progression of optic nerve damage.Elucidating these similarities and differences may facilitate early detection and targeted intervention strategies for at-risk individuals from a structural perspective.
Qing-Qing Mu;Ping Ge;Xu Liu;Jun Jia;Na Cui;Xiang-Xiang Yang;Rui-Xue Zhang;Yan Liu;Yuan-Yuan Zhang;Yuan He
Department of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,China Xi’an Medical University,Xi’an 710021,Shaanxi Province,ChinaDepartment of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,China Xi’an Medical University,Xi’an 710021,Shaanxi Province,ChinaDepartment of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,ChinaDepartment of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,ChinaDepartment of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,ChinaDepartment of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,ChinaDepartment of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,ChinaDepartment of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,China Xi’an Medical University,Xi’an 710021,Shaanxi Province,ChinaDepartment of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,China Xi’an Medical University,Xi’an 710021,Shaanxi Province,ChinaDepartment of Ophthalmology,the Second Affiliated Hospital of Xi’an Medical University,Xi’an 710038,Shaanxi Province,China Xi’an Medical University,Xi’an 710021,Shaanxi Province,China
医药卫生
non-pathologic high myopiaprimary open angle glaucomaoptic disclamina cribrosaretinal nerve fiber layer
《International Journal of Ophthalmology(English edition)》 2026 (6)
P.1177-1185,9
Supported by Xi’an Medical University“Yi zhen Gene Talent Cultivation Program”Student Research Project(No.2024YZ16)Xi’an Medical University 2024 First Batch of University-Level Research Fund(No.2024DXS03)Shaanxi Provincial Department of Education Young Innovative Team Research Program(No.24JP164)Education Department of Shaanxi Provincial Government for Youth Innovation Team Research Program Project(No.23JP151,No.23JP150)Project of the Scientific Research Capacity Enhancement Program of the Shaanxi Provincial Health Commission(No.2025YF-17).
评论