Hydrogen sulfide improves vascular endothelial function in hypertensive states through SIRT6 anti-inflammatory signalingOA
Hypertension is commonly accompanied by endothelial dysfunction,characterized by an imbalance between vasodilatation and constriction,increased levels of the proinflammatory factors interleukin-6(IL-6)and intercellular adhesion molecule-1(ICAM-1),and decreased nitric oxide(NO)bioavailability.Using an angiotensinⅡ(AngⅡ)-induced endothelial dysfunction model,we show that treatment with the hydrogen sulfide(H_(2)S)donor GYY4137 significantly reverses AngⅡ-induced damage.GYY4137 restores sirtuin 6(SIRT6)expression,suppresses inflammation,and improves vasodilatory function.Furthermore,endothelial-specific cystathionine-γ-lyase(CSE)-deficient mice exhibit inflammation and endothelial dysfunction in blood vessels,which is reversed by H_(2)S supplementation.Critically,SIRT6 inhibitors block the protective effects of H_(2)S in the endothelium.This study demonstrates that H_(2)S protects vascular endothelial function by activating the SIRT6 anti-inflammatory pathway.
Fan Lu;Xueyuan Qin;Shanshan Lu;Jie Wan;Yuxin Miao;Xu Teng;Sheng Jin;Lin Xiao;Hongmei Xue;Qi Guo;Danyang Tian;Yuming Wu
Department of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,China School of Clinical Medicine,North China University of Science and Technology,Tangshan 063210,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,China the Key Laboratory of Neural and Vascular Biology,Ministry of Education,Hebei Medical University,Shijiazhuang 050017,ChinaDepartment of Physiology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,China the Key Laboratory of Neural and Vascular Biology,Ministry of Education,Hebei Medical University,Shijiazhuang 050017,China Hebei Key Laboratory of Cardiovascular Homeostasis and Aging,Shijiazhuang 050017,China
医药卫生
hydrogen sulfideangiotensinⅡendothelial cellsinflammationSIRT6
《Acta Biochimica et Biophysica Sinica》 2026 (4)
P.845-853,9
supported by the grants from the National Natural Science Foundation of China(Nos.32271155,91849120,31871154,and 82300473)the National Natural Science Foundation of Hebei Province(No.H2025206072)the Innovation&Development Medical Cooperation Program of Hengrui-Hebei(No.HR202502001)the Key Laboratory of Neural and Vascular Biology,Ministry of Education of China(No.NV20230009).
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