Therapeutic potential of dihydrocapsaicin in vascular smooth muscle cell calcificationOA
Dihydrocapsaicin(DHC,C_(18)H_(29)NO_(3);Figure 1A)is the primary pungent component of natural capsaicinoids in chili peppers.DHC has diverse pharmacological and physiological properties,such as analgesia,anticancer,anti-inflammatory,antioxidant,and anti-obesity effects[1].These characteristics suggest its potential clinical applications in pain relief,cancer prevention,and weight loss,with benefits for the cardiovascular and gastrointestinal systems.Consequently,investigating the pharmacological and physiological effects and mechanisms of DHC has become a research hotspot in the food and pharmacological sciences.
Chenxi Li;Jiajun Chen;Zhiqing Liu;Hongling Zhu;Zeyu Huang;Qingyun Zhu;Lianyong Liu;Chaobao Zhang;Xiangqi Li
School of Gongli Hospital Medical Technology,University of Shanghai for Science and Technology,Shanghai 200093,ChinaSchool of Gongli Hospital Medical Technology,University of Shanghai for Science and Technology,Shanghai 200093,ChinaTraditional Chinese Medicine Department,Shanghai University of Medicine&Health Sciences,Shanghai 200135,ChinaDepartment of Endocrinology and Metabolism,Gongli Hospital,Shanghai University of Medicine&Health Sciences,Shanghai 200135,ChinaDepartment of Endocrinology and Metabolism,Punan Hospital of Shanghai Pudong New Area,Shanghai 200125,ChinaDepartment of Intervention,Gongli Hospital,Shanghai University of Medicine&Health Sciences,Shanghai 200135,ChinaDepartment of Endocrinology and Metabolism,Punan Hospital of Shanghai Pudong New Area,Shanghai 200125,ChinaShanghai Key Laboratory of Clinical Geriatric Medicine,Department of Geriatric Medicine,Huadong Hospital,Shanghai Medical College,Fudan University,Shanghai 200040,ChinaDepartment of Endocrinology and Metabolism,Gongli Hospital,Shanghai University of Medicine&Health Sciences,Shanghai 200135,China
医药卫生
pharmacological physiological propertiessuchphysiological effectsanalgesiapharmacological physiologdihydrocapsaicinvascular smooth muscle cell calcificationpharmacological effectspungent component
《Acta Biochimica et Biophysica Sinica》 2026 (4)
P.925-928,4
supported by the grants from the Key Discipline Construction Project of Pudong Health Bureau of Shanghai(No.PWZxk2022-29)the Science and Technology Committee of Pudong Shanghai(No.PKJ2023-Y29)the Gongli Hospital Incubation Project for National Natural Science Fund(No.2024GPY-A02)the National Clinical Research Center for Aging and Medicine Open Research Projects(No.2024KF1003)the One Health Fund Research Project for Aging and Medicine(No.C30-0101-0501).
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