An infection and pathogenesis mouse model of SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)OA
Impact statement SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR)is highly attenuated,but can cause mortality in a specifically designed human ACE2-transgenic mouse model,making it a surrogate model for evaluating the efficacy of vaccines and drugs against SARS-CoV-2.
Lai Wei;Shuiqing Liu;Shanshan Lu;Shengdong Luo;Xiaoping An;Huahao Fan;Erguang Li;Lihua Song
College of Life Science and Technology,Beijing University of Chemical Technology,Beijing,ChinaCollege of Life Science and Technology,Beijing University of Chemical Technology,Beijing,ChinaCollege of Life Science and Technology,Beijing University of Chemical Technology,Beijing,ChinaResearch Center for Clinical Medicine,The Fifth Medical Center of PLA General Hospital,Beijing,ChinaCollege of Life Science and Technology,Beijing University of Chemical Technology,Beijing,ChinaCollege of Life Science and Technology,Beijing University of Chemical Technology,Beijing,ChinaState Key Laboratory of Pharmaceutical Biotechnology,Medical School,Nanjing University,Nanjing,ChinaCollege of Life Science and Technology,Beijing University of Chemical Technology,Beijing,China
医药卫生
mouse modelsurrogate modelinfectionevaluating efficacy vaccines drugsGX P VSARS CoVpangolin coronaviruspathogenesis
《mLife》 2026 (2)
P.259-262,4
supported by the NSFC-MFST project(China-Mongolia)(grant number 32161143027).
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