胶原酶酶学清创在慢性创面治疗中的应用进展OA

Chronic wounds have emerged as a global public health concern,characterized by prolonged disease course,poor prognosis,and significant patient healthcare burden.Debridement,as a critical step in wound bed preparation,directly determines therapeutic outcomes.Enzymatic debridement refers to the selective application of enzymatic agents to necrotic tissue for targeted debridement.Among these,collagenase-based preparations are the most widely used and evidence-supported enzymatic debridement agents in clinical practice.They selectively degrade necrotic collagen without damaging healthy tissue,while also exerting multiple effects such as anti-inflammatory action,modulation of the wound microenvironment,promotion of granulation tissue formation,and enhancement of epithelialization.This article systematically reviews the historical development of enzymatic debridement,summarizes the mechanisms of collagenase-based preparations,and evaluates their clinical applications in burn wounds,diabetic foot ulcers,pressure ulcers,and vascular occlusive wounds.Furthermore,it provides insights based on the latest guidelines and research advancements to support standardized clinical practice.