泻肝止痛汤联合西药治疗肝经郁热型带状疱疹的疗效回顾分析OA

Objective:To investigate the efficacy and safety of Xiegan Zhitong Decoction combined with famciclovir tablets and mecobalamin tablets in treating herpes zoster with liver channel stagnation-heat syndrome.Methods:92 patients diagnosed with herpes zoster with liver channel stagnation-heat syndrome in the Department of Dermatology of Third Affiliated Hospital of Beijing University of Chinese Medicine from June 2022 to June 2024 were included.All patients received oral Xiegan Zhitong Decoction(1 dose/day,decocted in water)for one week as one treatment course,combined with famciclovir tablets for antiviral treatment and mecobalamin tablets for nerve nutrition.Clinical efficacy at different treatment courses,time-effect scores(time to stop blistering,crust formation time,crust shedding time,and pain relief time),pain and sleep scores,incidence of postherpetic neuralgia,and TCM syndrome scores were evaluated.Results:After treatment at each course,significant improvements were observed in time-effect scores,sleep and pain scores,and TCM syndrome scores(P<0.01,P<0.001).The cumulative effective rates at 1,2,3,and 4 weeks were 27.17%(25/92),88.04%(81/92),94.57%(87/92),and 98.91%(91/92)respectively.The incidence of postherpetic neuralgia was 1.09%(1/92).Conclusion:Xiegan Zhitong Decoction combined with famciclovir and mecobalamin tablets shows significant efficacy in treating herpes zoster with liver channel stagnation-heat syndrome,shortening recovery time,improving sleep,reducing pain,ameliorating TCM syndromes,with low incidence of postherpetic neuralgia and few adverse reactions.