注意力缺陷多动障碍动物模型的中西医临床病证特点评价分析OA

Objective:This article aims to evaluate and analyze existing animal models of attention deficit hyperac-tivity disorder(ADHD)based on the clinical symptom characteristics of ADHD in traditional Chinese medicine(TCM)and Western medicine,so as to provide a theoretical basis for the advancement of ADHD research and development.Methods:Through computer database retrieval,the existing ADHD animal modeling methods in China and abroad were summarized,and by reviewing the relevant literature on ADHD and its animal models,the etiology,pathogenesis,and di-agnostic criteria of TCM and Western medicine were compiled and summarized.According to the clinical symptom char-acteristics in TCM and Western medicine,an evaluation system for animal models was established,and the model's clini-cal fit in TCM and Western medicine was systematically quantified using the method of assignment so that the characteris-tics of the ADHD animal model could be visualized and comprehensively analyzed,and its advantages and disadvantages could be elucidated.Results:A total of 60 articles were included,containing 35 types of ADHD animal models,which were classified into three categories:genetic models,chemical/environmental induction models,and multifactor models.In the evaluation and analysis of the above ADHD animal models,it is found that compared with chemical/environmental induction models,genetic models have a greater variety of modeling methods and a more advantageous clinical fit in TCM and Western medicine.The spontaneously hypertensive rat(SHR)model has the highest clinical fit in TCM and West-ern medicine,with the advantages of good reproducibility and low cost.It is also found that the clinical fit in Western medicine is generally higher than the clinical fit in TCM,and there is a lack of ADHD animal models with multiple factors and symptoms in TCM.Conclusions:Most existing models use single-factor modeling methods,with less symptom repre-sentation in TCM.In the future,it is necessary to actively develop ADHD animal models highly compatible with the clini-cal symptom characteristics in TCM and Western medicine.