防己地黄汤临床应用、药理作用、化学成分的研究进展及质量标志物预测OA

Fangji Dihuang Decoction,originating from the Jin Gui Yao Lve,possesses the effects of nourishing yin,cooling blood,dispelling wind,and unblocking meridians.It is indicated for conditions such as mania and limb pain caused by wind pathogen affecting the shaoyin meridian.Clinically,Fangji Dihuang Decoction is frequently used to treat systemic lupus erythematosus,the manic phase of bipolar disorder,and chronic nephritis,achieving satisfactory therapeutic outcomes.Studies have revealed that Fangji Dihuang Decoction primarily contains chemical components such as iridoid glycosides,alkaloids,flavonoids,coumarins,and triterpenes,exhibiting significant pharmacological effects including anti-inflammatory,renal protective,and neuroprotective activities.Research on quality marker prediction suggests that catalpol,tetrandrine,prim-O-glucosylcimifugin,cinnamaldehyde,and glycyrrhizic acid are candidate components with strong correlations between the intrinsic quality of Fangji Dihuang Decoction and its clinical efficacy.This article systematically summarizes the research progress on the clinical application,pharmacological effects,chemical constituents,and quality marker prediction of Fangji Dihuang Decoction,aiming to provide a theoretical basis for the standardized development and clinical promotion of this formula.