中医治疗老年男性骨质疏松症的临床研究进展OA

Osteoporosis(OP)is a systemic skeletal disorder characterized by reduced bone mass,deterioration of bone microarchitecture,and increased bone fragility,posing a serious threat to the quality of life and safety of the elderly.With the accelerating trend of population aging,the incidence of OP among older men has been rising annually,accompanied by significantly higher rates of disability and mortality due to fractures compared to women.This has emerged as a critical issue requiring urgent attention in the field of bone metabolic disease prevention and treatment.However,current medical interventions for OP in older men remain limited.Conventional therapies such as bisphosphonates are often associated with notable gastrointestinal side effects and suboptimal long-term adherence,rendering their clinical efficacy inadequate to meet practical needs.Traditional Chinese medicine(TCM),with its distinctive strengths in holistic regulation and multi-target interventions,has increasingly become an important complementary approach for the prevention and management of OP in older males.According to TCM theory,kidney deficiency,spleen-stomach weakness,and blood stasis constitute the core pathogenesis of OP in elderly men.This article systematically reviews recent relevant literature and integrates TCM pathological mechanisms with existing clinical and experimental findings to summarize the physiological characteristics and disease progression patterns of OP in older men.It highlights advancements in the application of single herbs and compound formulations in internal TCM treatments for syndromes such as kidney Yang(阳)deficiency,spleen-stomach weakness,and kidney deficiency with blood stasis.Additionally,the clinical benefits of external treatments—including acupuncture,moxibustion,catgut embedding,acupotomy,and Tuina—in alleviating pain,regulating bone metabolism,and enhancing quality of life are summarized.In light of the current research status,this paper also identifies limitations in existing studies concerning sample size,syndrome standardization,and mechanistic depth.Furthermore,it discusses strategies for optimizing acupuncture-based clinical protocols and outlines future research directions,aiming to provide higher-quality evidence-based medical support and theoretical foundations for clinical practice.The ultimate goal is to promote the standardized application and innovative development of TCM in the prevention and treatment of OP in older men.