八段锦干预2型糖尿病的作用机制研究进展OA

Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease primarily characterized by insulin resistance and progressive dysfunction of pancreatic β-cells.Its global prevalence continues to rise,making it a major public health issue that severely impacts population health.The pathogenesis of T2DM is closely associated with insulin resistance,disregulation of glucose and lipid metabolism,and chronic inflammatory responses.As a representative traditional Chinese exercise,Baduanjin(八段锦)originated in the Northern Song Dynasty and has a history of over 800 years.Its movements are slow,continuous,and integrate form with spirit,emphasizing a triadic exercise mode of"regulating the body,breath,and mind".The practice demonstrates potential for multi-dimensional intervention for T2DM.On one hand,it can improve insulin sensitivity and promote glucose transport.On the other hand,it can reduce levels of inflammatory factors such as TNF-α and IL-6,modulate the composition of gut microbiota,and optimize glucose and lipid metabolism.Furthermore,Baduanjin can improve vascular endothelial function,thereby reducing the risk of cardiovascular complications.It also helps alleviate negative emotions and enhance psychological resilience by regulating the autonomic nervous system function.Clinical studies have shown that Baduanjin can significantly lower fasting plasma glucose and HbA1c levels in T2DM patients and delay the progression of glucose metabolic disorders by 5 to 7 years.Compared to pharmacological treatments,Baduanjin offers unique advantages:it is free of adverse reactions,low-cost,easy to perform,sustainable,and can comprehensively improve quality of life.These characteristics make it particularly suitable for community promotion and long-term home-based rehabilitation for patients.This article aims to systematically review and elucidate the research progress on the multi-target mechanisms of Baduanjin in intervening T2DM,including improving insulin sensitivity,exerting anti-inflammatory effects,modulating gut microbiota,protecting vascular health,and promoting mental well-being.This provides new insights for the integrated prevention and treatment strategy of diabetes that combines Chinese and Western medicine.