IL-22/STAT3信号通路在肠黏膜损伤修复中的作用及机制研究进展OA
Research Progress on the Role and Mechanisms of the IL-22/STAT3 Signaling Pathway in the Repair of Intestinal Mucosal Injury
肠黏膜损伤是多种肠道疾病的共同病理表现,一旦发生可导致通透性增加、菌群易位并加重病情.IL-22 是一个重要免疫调节因子,可激活STAT3 信号通路,在促进肠上皮细胞的增殖与分化、抑制细胞凋亡,维持肠道屏障完整性方面有重要作用.虽然已有研究显示IL-22/STAT3 通路在肠黏膜修复中扮演重要角色,但具体分子机制及复杂的信号调控网络,仍存在许多未知.文章旨在系统梳理该信号通路在肠黏膜修复中的最新研究进展,着重探讨其在调控细胞增殖、炎症反应以及维护屏障功能等方面的作用机制,以期为肠道疾病的精准治疗提供理论参考与潜在靶点,并推动相关临床研究的深入.
Intestinal mucosal injury is a common pathological manifestation of various intestinal disorders.Its occurrence can lead to increased permeability,bacterial translocation,and exacerbation of the disease.IL-22 is an important immunomodulatory factor that activates the STAT3 signaling pathway and plays a significant role in promoting the proliferation and differentiation of intestinal epithelial cells,inhibiting apoptosis,and maintaining intestinal barrier integrity.Although studies have indicated the involvement of the IL-22/STAT3 pathway in intestinal mucosal repair,the specific molecular mechanisms and complex signaling regulatory networks remain largely unclear.The study aims to systematically review recent research advances regarding this signaling pathway in intestinal mucosal repair,with a focus on its mechanisms in regulating cell proliferation,inflammatory responses,and maintaining barrier function.The goal is to provide theoretical references and potential therapeutic targets for the precise treatment of intestinal diseases and to promote further clinical research in this field.
苏文松;占凌辉
厦门大学附属中山医院 福建 厦门 361000厦门大学附属中山医院 福建 厦门 361000
IL-22/STAT3信号通路肠黏膜损伤修复机制肠道屏障
IL-22/STAT3 signaling pathwayIntestinal mucosal injuryRepair mechanismIntestinal barrier
《中外医学研究》 2026 (13)
146-152,7
厦门市自然科学基金项目(3502Z20227352)
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