隔药饼灸神阙治疗寒凝血瘀型原发性痛经:一项随机对照试验OA
Herb cake-insulated moxibustion at Shenque(CV8)for primary dysmenorrhea of cold-induced blood stasis pattern:a randomized controlled trial
目的:观察隔药饼灸神阙治疗寒凝血瘀型原发性痛经的临床疗效及对血清炎症因子的影响.方法:根据随机数字表法将60例寒凝血瘀型原发性痛经患者随机分为隔药灸组和药物组,每组30例.药物组口服布洛芬缓释胶囊治疗,自月经来潮前3 d开始用药,持续至经期结束.隔药灸组给予隔药饼灸神阙治疗,于月经来潮前3 d开始施灸,每日1次,持续至经期结束.两组均以1个月经周期为1个疗程,共治疗3个疗程.观察治疗前后疼痛视觉模拟量表(VAS)评分和中医症状评分;检测两组患者治疗前后血清炎症因子白细胞介素(IL)-6、前列腺素(PG)F2α、PGE2和β内啡肽(β-EP)含量变化,并评估两组临床疗效.结果:治疗后隔药灸组总有效率93.3％,与药物组的80.0％相比无统计学差异(P>0.05).治疗后,两组患者VAS评分及中医症状评分均较治疗前降低(P<0.05),且隔药灸组低于药物组(P<0.05).治疗后,隔药灸组IL-6和PGF2α含量均较治疗前降低(P<0.05),且低于药物组(P<0.05);PGE2和β-EP含量均升高(P<0.05),且高于药物组(P<0.05).结论:隔药饼灸神阙可以减轻寒凝血瘀型原发性痛经患者的疼痛程度,改善痛经临床症状,降低血清IL-6和PGF2α水平,升高PGE2和β-EP含量.
Objective:To observe the clinical efficacy of herb cake-insulated moxibustion at Shenque(CV8)in treating primary dysmenorrhea(PD)of cold-induced blood stasis pattern,and its influence on serum inflammatory factors. Methods:A total of 60 patients with PD of cold-induced blood stasis pattern were randomly divided into an herb cake-insulated moxibustion group and a medication group by the random number table method,with 30 cases in each group.The medication group was treated with oral ibuprofen sustained-release capsules,initiated 3 d before menstruation and continued until the end of the menstrual period.The herb cake-insulated moxibustion group received herb cake-insulated moxibustion at Shenque(CV8),once daily starting 3 d before menstruation until menstruation ended.One menstrual cycle was defined as one treatment course,and both groups received treatment for 3 courses in total.The scores of visual analog scale(VAS)and traditional Chinese medicine symptoms were observed and recorded before and after treatment.In both groups,changes in the serum levels of interleukin(IL)-6,prostaglandin(PG)F2α,PGE2,and β-endorphin(β-EP)were determined before and after treatment.The clinical efficacy was evaluated. Results:The total effective rate was 93.3%in the herb cake-insulated moxibustion group and 80.0%in the medication group,showing no statistically significant difference between the two groups(P>0.05).After treatment,the VAS and traditional Chinese medicine symptom scores decreased significantly in both groups compared with baseline(P<0.05),and the herb cake-insulated moxibustion group showed lower scores than the medication group(P<0.05).The serum levels of IL-6 and PGF2α were reduced in the herb cake-insulated moxibustion group after treatment(P<0.05)and were lower than those in the medication group(P<0.05).The herb cake-insulated moxibustion group also showed increased levels of PGE2 and β-EP after treatment(P<0.05),which were higher than those in the medication group(P<0.05). Conclusion:Herb cake-insulated moxibustion at Shenque(CV8)can alleviate pain and relieve clinical symptoms in patients with PD of cold-induced blood stasis pattern,and can downregulate serum IL-6 and PGF2α levels while upregulating PGE2 and β-EP contents.
赵敏;陶欢;窦婷婷;王利军;刘灵儿
医药卫生
灸法间接灸药饼灸疗法穴,神阙痛经寒凝血瘀证随机对照试验
Moxibustion TherapyIndirect MoxibustionHerb Cake-insulated MoxibustionPoint,Shenque(CV8)DysmenorrheaCold-induced Blood Stasis PatternRandomized Controlled Trial
《针灸推拿医学（英文版）》 2026 (3)
292-299,8
This study was supported by Innovative Fund Project for University Teachers in Gansu Province in 2024(2024年甘肃省高校教师创新基金项目,No.2024A-217).
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