天然血管舒张剂:在心血管疾病中的作用机制与治疗潜力OA
Natural vasodilators:mechanisms and therapeutic potential in cardiovascular diseases
天然血管舒张剂凭借疗效确切、获取便捷、安全性良好等优势,在高血压、心绞痛及心力衰竭等心血管疾病的治疗中逐步得到认可,是具有应用价值的替代治疗方案.文章系统检索PubMed和中国知网数据库,筛选得到227种具有显著血管舒张活性的天然化合物,介绍黄酮类、皂苷类、酚类、生物碱类等核心植物化学成分的血管舒张作用,梳理支撑其临床应用的临床前研究证据,并阐释天然化合物发挥血管舒张效应的潜在作用机制,主要包括内皮依赖性血管张力调控、平滑肌离子通道调控、缓解氧化应激及拮抗肾素-血管紧张素-醛固酮系统等.上述机制有助于阐明天然血管舒张剂的作用机理,为心血管疾病的临床治疗提供新策略.
Natural products with vasodilatory properties are increasingly recognized for treating hypertension,angina,and heart failure owing to their efficacy,accessibility,and favorable safety profiles,rendering them viable therapeutic alternatives.Following a systematic search of the NCBI PubMed and CNKI databases,227 natural compounds with potent vasodilatory activity were identified.This review delineates the vasodilatory effects of major phytochemical classes-specifically flavonoids,saponins,phenols,and alkaloids-and evaluates preclinical evidence supporting their therapeutic application.Furthermore,potential vasodilatory mechanisms are elucidated,encompassing endothelium-dependent regulation of smooth muscle tone,fluid homeostasis,oxidative stress mitigation,and antagonism of the renin-angiotensin-aldosterone system.These mechanisms clarify the pharmacological basis of natural vasodilators,offering researchers and clinicians enhanced strategies for managing cardiovascular diseases.
孙傲梅;Dake Qi;王启隆;Opoku Bonsu Francis;严舒桐;王静;赵皓爽;冷玲;黎瑞巧;刘洪涛;田晓轩
天津中医药大学中医药研究院,天津加拿大曼尼托巴大学 Rady 健康科学学院药学系,温尼伯市天津中医药大学中医药研究院,天津||现代中药创制全国重点实验室,天津||天津中医药大学第四附属医院内分泌科,天津天津中医药大学中医药研究院,天津天津中医药大学中医药研究院,天津天津中医药大学中医药研究院,天津天津中医药大学中医药研究院,天津天津中医药大学中医药研究院,天津||现代中药创制全国重点实验室,天津天津中医药大学中医药研究院,天津湖北中医药大学中药资源与中药复方教育部重点实验室,武汉天津中医药大学中医药研究院,天津||现代中药创制全国重点实验室,天津
天然化合物血管舒张舒张因子离子通道肾素-血管紧张素-醛固酮系统人参皂苷小檗碱白藜芦醇
Natural productsVasodilationVasodilatory factorsIon ChannelRAASGinsenosidesBerberineResveratrol
《针灸和草药（英文）》 2026 (2)
155-187,33
This study was supported by the National Key R&D Program of China(2022YFC3501800,2024YFC3505104),National Natural Science Foundation of China(No.82474310),and Key Laboratory of Chinese Medicinal Resource and Chinese Herbal Compound of the Ministry of Education Funding(KF2024001).
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