糖尿病酮症酸中毒合并小孢根霉、新型冠状病毒感染1例OA

A 48-year-old male patient presented with fever up to 39.2℃,accompanied by cough and expectoration,with no obvious predisposing cause 12 days prior to admission.SARS-CoV-2 antigen test was positive in outpatient setting.After admission,the patient presented with persistent high fever,cough,expectoration,hemoptysis and pleuritic chest pain.Diabetes mellitus was diagnosed.Chest CT revealed multiple pulmonary lesions with halo sign and reversed halo sign.On the 4th day after admission,broad,septate hyphae were identified in bronchoalveolar lavage fluid smears.However,the patient's condition deteriorated rapidly,complicated by dyspnea and metabolic acidosis,and the patient died due to ineffective treatment.Subsequently,fungal culture of bronchoalveolar lavage fluid yielded Rhizopus species,which was further identified as Rhizopus microsporus using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS)and targeted sequencing.Clinicians should be aware that diabetes mellitus can accelerate the progression of pulmonary mucormycosis,and enhance their understanding of the clinical diagnosis and management features of pulmonary mucormycosis