朱琏针灸兴奋法对缺血性脑卒中恢复期患者肢体功能及血清氧化应激指标、血管生成因子的影响OA
Effects of ZHU Lian's excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes,angiogenic factors in patients with ischemic stroke during the recovery period
目的:观察朱琏针灸兴奋法对缺血性脑卒中恢复期患者肢体功能及血清氧化应激指标、血管生成因子的影响.方法:将84例缺血性脑卒中恢复期患者随机分为朱琏针灸组(42例,脱落 5例)和常规针刺组(42例,脱落 8 例).在常规治疗基础上,朱琏针灸组予朱琏针灸兴奋法治疗,常规针刺组予常规针刺治疗,均穴取患侧风池、肩髃、曲池、外关、新设、肩髎、新义、合谷等.均每日1次,共治疗3周.观察两组患者治疗前后Fugl-Meyer运动功能评定量表(FMA)、Berg平衡量表(BBS)、改良Barthel指数(MBI)评分和血清超氧化物歧化酶(SOD)、丙二醛(MDA)、还原型谷胱甘肽(GSH)、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、内皮素-1(ET-1)含量.结果:与治疗前比较,两组患者治疗后FMA、BBS、MBI评分及血清SOD、GSH、VEGF、bFGF含量均升高(P＜0.001,P＜0.05,P＜0.01),血清MDA、ET-1含量降低(P＜0.001);治疗后,朱琏针灸组患者FMA、BBS、MBI 评分及血清SOD、GSH、VEGF、bFGF含量均高于常规针刺组(P＜0.05,P＜0.001),血清MDA、ET-1含量低于常规针刺组(P＜0.001,P＜0.01).结论:朱琏针灸兴奋法可能通过调节缺血性脑卒中恢复期患者抗氧化能力和血管生成发挥神经保护效应,从而改善患者肢体功能.
Objective To observe the effects of ZHU Lian's excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes,and angiogenic factors in patients with ischemic stroke during the recovery period.Methods A total of 84 patients with ischemic stroke during the recovery period were randomly divided into a ZHU Lian acupuncture group(42 cases,5 cases dropped out)and a conventional acupuncture group(42 cases,8 cases dropped out).On the basis of routine treatment,the ZHU Lian acupuncture group received ZHU Lian's excitation-type acupuncture manipulation,while the conventional acupuncture group received conventional acupuncture treatment.Acupoints on the affected side were selected,including Fengchi(GB20),Jianyu(LI15),Quchi(LI11),Waiguan(TE5),Xinshe(Extra),Jianliao(TE14),Xinyi(Extra),Hegu(LI4),etc.Treatments were administered once daily for 3 weeks in both groups.The Fugl-Meyer assessment(FMA),Berg balance scale(BBS),modified Barthel index(MBI)scores and serum levels of superoxide dismutase(SOD),malondialdehyde(MDA),reduced glutathione(GSH),vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF),endothelin-1(ET-1)were observed before and after treatment in both groups.Results Compared with before treatment,the FMA,BBS,MBI scores and serum levels of SOD,GSH,VEGF,bFGF after treatment were increased in both groups(P＜0.001,P＜0.05,P＜0.01),and serum levels of MDA and ET-1 were decreased(P＜0.001);after treatment,the FMA,BBS,MBI scores and serum levels of SOD,GSH,VEGF,bFGF in the ZHU Lian acupuncture group were higher than those in the conventional acupuncture group(P＜0.05,P＜0.001),and serum levels of MDA and ET-1 in the ZHU Lian acupuncture group were lower than those in the conventional acupuncture group(P＜0.001,P＜0.01).Conclusion ZHU Lian's excitation-type acupuncture manipulation may exert neuroprotective effects in patients with ischemic stroke during the recovery period by modulating antioxidant capacity and angiogenesis,thereby improving limb function.
翟阳;梅小平;舒建龙;王瀚;高阳;黎芳;莫智珍;黄桂课;韦玉鲁;池腾飞;邹敏;庞延
南宁市第七人民医院/南宁市针灸研究所,脑病科,广西 南宁 530012广西国际壮医医院/广西中医药大学附属国际壮医医院,脑病科南宁市第七人民医院/南宁市针灸研究所,脑病科,广西 南宁 530012南宁市第七人民医院/南宁市针灸研究所,脑病科,广西 南宁 530012南宁市第七人民医院/南宁市针灸研究所,脑病科,广西 南宁 530012南宁市第七人民医院/南宁市针灸研究所,针灸康复一区,广西 南宁 530012南宁市第七人民医院/南宁市针灸研究所,针灸康复一区,广西 南宁 530012南宁市第七人民医院/南宁市针灸研究所,脑病科,广西 南宁 530012南宁市第七人民医院/南宁市针灸研究所,脑病科,广西 南宁 530012南宁市第七人民医院/南宁市针灸研究所,脑病科,广西 南宁 530012广西国际壮医医院/广西中医药大学附属国际壮医医院,儿科广西中医药大学第一附属医院仁爱分院
缺血性脑卒中恢复期朱琏针灸兴奋法肢体功能氧化应激血管生成随机对照试验
ischemic stroke during the recovery periodZHU Lian's excitation-type acupuncture manipulationlimb functionoxidative stressangiogenesisrandomized controlled trial(RCT)
《中国针灸》 2026 (6)
861-867,7
广西自然科学基金资助项目:2024GXNSFAA010252、2025GXNSFBA0693082024年广西青年岐黄学者培养项目:GXQH2024192025年广西中医药适宜技术开发与推广项目:GZSY20250862025年广西中医药大学联合基金项目:2025NN001广西壮族自治区中医药管理局自筹课题项目:GXZYA20230437
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