精制菖芩1号治疗痰瘀热结型重型创伤性脑损伤临床疗效观察OA
Clinical efficacy of refined Changqin No.1 decoction in treatment for severe traumatic brain injury with syndrome of phlegm-stasis-heat syndrome
目的 探讨精制菖芩1号对痰瘀热结型重型创伤性脑损伤患者的临床疗效及预后影响.方法 共纳入70例重型创伤性脑损伤患者,随机分为中药组(35例)和对照组(35例).对照组予西医基础治疗,中药组在对照组治疗基础上加用精制菖芩1号,每日1剂,分2次胃管鼻饲给药或口服.连续治疗14 d.治疗结束后1个月,比较两组患者临床有效率、预后情况[格拉斯哥预后评分(GOS评分)]及药物不良反应发生率.结果 治疗结束后1个月,中药组治疗有效率为82.86%(29/35例),对照组为57.14%(20/35例)(P<0.05).中药组GOS评分为(3.23±0.49)分,对照组为(2.97±0.45)分,两组比较差异有统计学意义(P<0.05).中药组肝功能不全、肾功能不全、皮疹发生率分别为17.14%、8.57%、11.43%;对照组分别为11.43%、8.57%、5.71%,组间比较差异均无统计学意义(P>0.05).结论 精制菖芩1号可显著提高痰瘀热结型重型创伤性脑损伤患者临床有效率,显著改善患者预后(以GOS评分评估),且未增加药物相关不良反应.
[Objective]To investigate the clinical efficacy and prognostic impact of refined Changqin No.1 decoction in patients with severe traumatic brain injury(TBI)of the phlegm-stasis-heat syndrome type.[Methods]A total of 70 severe TBI patients were enrolled and randomly assigned to either the Chinese medicine group(35 cases)or the control group(35 cases).The control group received standard Western medical treatment,while the Chinese medicine group was additionally administered refined Changqin No.1 decoction(one dose daily,divided into two nasogastric or oral administrations)for 14 consecutive days.Clinical effectiveness,prognosis[assessed by Glasgow Outcome Scale(GOS)score],and adverse drug reactions were compared between the two groups at 1 month post-treatment.[Results]At 1 month post-treatment,the clinical effectiveness rate was 82.86%(29/35)in the Chinese medicine group and 57.14%(20/35)in the control group,with a statistically significant difference(P<0.05).The GOS score in the Chinese medicine group(3.230±0.49)was significantly higher than that in the control group(2.97±0.45)(P<0.05).The incidence rates of liver dysfunction,renal dysfunction,and rash in the Chinese medicine group were 17.14%,8.57%,and 11.43%,respectively,compared with 11.43%,8.57%,and 5.71%in the control group,with no statistically significant differences(P>0.05).[Conclusion]Refined Changqin No.1 Decoction significantly improves clinical effectiveness and prognosis(GOS score)in severe TBI patients with phlegm-stasis-heat syndrome without increasing drug-related adverse reactions.
夏明月;谢叶丽;戴幸平;王东生;余文婷
中南大学湘雅医院江西医院 国家神经疾病区域医疗中心,江西 南昌 330038中南大学湘雅医院江西医院 国家神经疾病区域医疗中心,江西 南昌 330038中南大学湘雅医院江西医院 国家神经疾病区域医疗中心,江西 南昌 330038中南大学湘雅医院江西医院 国家神经疾病区域医疗中心,江西 南昌 330038中南大学湘雅医院江西医院 国家神经疾病区域医疗中心,江西 南昌 330038
医药卫生
精制菖芩1号重型创伤性脑损伤临床疗效
refined Changqin NO.1 decoctionsevere traumatic brain injuryclinical efficacy
《中国医学工程》 2026 (5)
65-69,5
国家自然科学基金面上项目(82474283)湖南省科技重大专项子项目四(2020SK1014-4)
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