3D打印聚乳酸施源器在宫颈癌近距离治疗中的应用研究OA

[Objective]To study the application of polylactic acid(PLA)materials processed by 3D printing technology in the treatment of brachytherapy afterloading,and to obtain the application effect of PLA applicator through the dosimetry comparison between the PLA source applicator and the conventional titanium alloy three-tube source applicator,so as to provide guidance for the application of PLA source applicator.[Methods]This study was a prospective study,and 10 patients with cervical cancer in The University of Hong Kong Shenzhen Hospital from January 2024 to October 2024 were selected,and all 10 patients were treated with 4 fractions of afterloading of 6 Gy each time,of which the first two times were treated with a titanium alloy three-tube applicator as the control group,and the last two times were treated with a 3D printed PLA source device as the test group.The D90 reference dose of high-risk clinical target volume(HR-CTV)and the D2cc dose of organs at risk(OAR)such as bladder and rectum were analyzed and compared between the two groups.[Results]The average value of HR-CTV D90 in the experimental group using the 3D printed PLA applicator was 691.2±149.2 cGy,while the average HR-CTV D90 in the control group using the titanium alloy three-tube applicator was 619.0±141.0 cGy.The comparison between the two groups showed that the target dose of the PLA applicator test group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).In the comparison of bladder and rectal D2cc,the dose distribution in the experimental group was more stable and concentrated,and the dose was lower than that of the control group(P<0.05).[Conclusion]The treatment method of 3D printed PLA applicator shows better target conformity in the treatment of cervical cancer,and at the same time reduces the radiation dose of rectum and bladder,showing certain therapeutic advantages,and PLA materials are suitable for the treatment of cervical cancer.