乙酰辅酶A酰基转移酶2在动物脂肪代谢调节中的作用机制研究进展OA

The metabolism of animal fats usually maintains a dynamic equilibrium within the body.Once this balance is disrupted,it may lead to lipid metabolism disorders,which can subsequently affect animal health by increasing the risk of metabolic diseases,inducing oxidative stress and chronic inflammation,and causing insulin resistance,among other pathways.One of the current efficient approaches is to regulate the expression levels of key factors involved in fat metabolism to change the direction of fat metabolism.Acetyl-CoA acyltransferase 2(ACAA2),as a key enzyme in the fatty acid catabolic pathway,catalyzes critical reactions during fatty acid β-oxidation and is crucial for maintaining the balance of fat metabolism.This article introduces the hazards of lipid metabolism disorders in animals and the regulatory factors,analyzes the biological functions,transcriptional regulation and post-translational modifications of ACAA2,and summarizes its roles and mechanisms in lipid metabolism regulation in animal liver tissues,adipose tissues and cardiovascular systems.Research on ACAA2 is expected to provide effective prevention and treatment strategies and theoretical basis for improving lipid metabolism disorders in animals and the associated series of metabolic diseases.