高频振荡通气联合布地奈德持续雾化吸入治疗新生儿呼吸窘迫综合征的效果研究OA

Objective To investigate the effect of high-frequency oscillatory ventilation(HFOV)combined with continuous nebulized budesonide in the treatment of neonatal respiratory distress syndrome(NRDS).Methods A total of 84 neonates with NRDS were selected from our hospital between January 2022 and September 2024.Using a random number table method,they were randomly divided into the control group(treated with HFOV)and the observation group(treated with HFOV combined with continuous nebulized budesonide),with 42 cases in each group.Clinical efficacy,respiratory mechanics indicators[(intrinsic positive end-expiratory pressure,airway resistance,respiratory index(RI)],blood gas indicators[partial pressure of carbon dioxide(PaCO2),partial pressure of oxygen(PaO2),fraction of inspired oxygen(FiO2),blood pH value],myocardial injury and oxidative stress indicators[serum cardiac troponin I(cTnI),creatine kinase isoenzyme(CK-MB),malondialdehyde(MDA)levels],ventilation-related parameters(duration of mechanical ventilation,duration of oxygen therapy,and frequency of apnea episodes),and the safety of the treatment were compared between the groups.Results The overall response rate was significantly higher in the observation group than in the control group(P＜0.05).The differences in intrinsic positive end-expiratory pressure,airway resistance,and RI before and after treatment were significantly greater in the observation group than in the control group(P＜0.05).The decreases in PaCO2 and FiO2,as well as the increases in PaO2 and pH,were significantly greater in the observation group than in the control group(P＜0.05).The differences in cTnl,CK-MB,and MDA levels before and after treatment were significantly greater in the observation group than in the control group(P＜0.05).The duration of mechanical ventilation and the duration of oxygen therapy were shorter,and the number of apnea episodes was lower in the observation group than in the control group(P＜0.05).A comparison of the incidence of bronchopulmonary dysplasia between the observation group and the control group showed a statistically significant difference according to the x2 test(x2=3.896,P=0.048).Conclusion HFOV combined with continuous nebulized budesonide effectively improves respiratory mechanics and blood gas status in neonates with NRDS,reduces myocardial injury and oxidative stress levels,shortens the duration of mechanical ventilation and oxygen therapy,and lowers the incidence of adverse events,indicating good clinical application value.