首页|期刊导航|中国实用内科杂志|《拯救脓毒症运动:脓毒症及感染性休克管理国际指南2026》要点解读与思考

《拯救脓毒症运动:脓毒症及感染性休克管理国际指南2026》要点解读与思考OA

Interpretation and thinking of keypoints in Surviving Sepsis Campaign:International Guidelines for Management of Sepsis and Septic Shock 2026

中文摘要英文摘要

《拯救脓毒症运动:脓毒症及感染性休克管理国际指南2026》(以下简称2026版指南)的核心及更新内容主要体现在5方面.对于院前筛查与早期管理,强调建立标准化预警响应流程,将治疗时间窗前移.建立个体化血压目标和复苏策略,避免液体不足或过度复苏.对抗生素使用时机进行更精细的风险分层,旨在平衡"不延误治疗"与"避免不必要的抗生素暴露".因现有证据有限,该版指南对于大部分附加治疗持反对意见,以避免无效干预增加医疗成本和潜在风险.关注长期预后与幸存者照护,建议卫生系统实施过渡期管理并制定个体化出院计划.2026版指南在制定过程中更加严谨透明,在推进脓毒症全周期、精准化管理的同时,也清醒认识到循证医学证据与临床现实之间的差距.该指南并非提供统一答案,而是明确指出哪些意见有证据支持,哪些是当前通用实践,哪些需要个体化决策.其根本目的在于指导临床行为不发生严重偏倚,保证基本医疗安全与质量,最终实现以患者为中心的个体化治疗.

The core and updated contents of the"Surviving Sepsis Campaign:International Guidelines for Management of Sepsis and Septic Shock 2026"are mainly reflected in five aspects.It advocates for individualized blood pressure targets and resuscitation strategies to avoid insufficient or excessive fluid resuscitation.The timing of antimicrobial therapy is based on risk stratification,aiming to balance"delaying treatment"with"unnecessary antibiotic exposure".Due to the limited evidence,most additional treatments are opposed to avoid increasing costs and potential risks.It also focuses on long-term outcomes and recovery,suggests health systems offering post critical illness follow-up services.The 2026 guidelines were developed with greater rigor and transparency.Efforts were made to promote the full-cycle management of sepsis.It recognizes the gap between evidence and reality.The guidelines do not provide uniform answers but clearly indicate which opinions are supported by evidence,which are common practices,and which require individualized decisions.The purpose of guidelines is to guide clinical behavior without significant bias,improve medical quality,and achieve patient-centered treatment.

陈铭铭;马晓春;朱然

中国医科大学附属第一医院重症医学科,辽宁 沈阳 110001中国医科大学附属第一医院重症医学科,辽宁 沈阳 110001中国医科大学附属第一医院重症医学科,辽宁 沈阳 110001

医药卫生

脓毒症感染性休克指南解读液体复苏长期预后

sepsisseptic shockguideline interpretationfluid resuscitationlong-term outcomes

《中国实用内科杂志》 2026 (6)

491-494,4

科技部"十四五"国家重点研发计划(2021YFC2500805)

10.19538/j.nk2026060109

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