宠物抗真菌药伊曲康唑溶液与分散片药代动力学研究OA

This study aimed to establish a pharmacokinetic research method for itraconazole(ITZ),evaluate the pharmacokinetic parameters of commercially available itraconazole preparations and provide a reference for veterinary clinical medication and drug development.Eight healthy British shorthairs with a weight range of 2.6 to 4.2 kg,half male and half female,were randomly divided into two groups according to experimental requirements.Each cat was administered with single dose of itraconazole oral solution at 5 mg/kg or dispersible tablets at 10 mg/kg.The relevant pharmacokinetic parameters were analyzed and calculated using the DAS2.0 non atrioventricular kinetic model.The main pharmacokinetic parameters of itraconazole oral solution were summarized as follows:t1/2(32.45±43.19)h,Tmax(2.75±1.58)h,Cmax(0.752±0.146)μ g/mL,AU C0-t(15.01±5.26)μg/mL*h,AUC0-∞(21.94±19.00)μg/mL* h,MRT(49.59±56.91)h,Vz/F(329.13±15 7.74)L/kg,CLz/F(0.7 5±0.15)L/h/kg,Fr el(218.3 9%).T he main pharmacokinetic parameters of itraconaz ole dispersible tablets were listed below:t1/2(52.68±44.52)h,Tmax(3.1 3±1.13)h,Cmax(0.16±0.08)μg/mL,AUC0-t(3.07±1.32)μg/m L*h,AUC0-∞(5.02±3.69)μg/mL*h,MRT(67.13±66.00),V z/F(1 73.91±78.11)L/kg,C Lz/F(3.22±2.69)L/h/kg,Fre l(45.79%).In concl usion,the bl ood itraconazole concentration was much lower than the effective range mentioned in the literature for treating fungal infections when the single dosage of oral dispersible tablets was administered at 10 mg/kg.Therefore,it is recommended to increase the dosage when dispersible tablets were used for the treatment of fungal infections.