NETosis在ARDS中的作用机制及组蛋白修饰对其的调控作用OA

Acute respiratory distress syndrome(ARDS)is a common critical disease in clinical practice.Neutrophil extracellular traps(NETs)play a dual role in its pathogenesis,acting as an important immune defense mechanism and a key factor leading to lung tissue damage.Neutrophil extracellular traps formation(NETosis)is precisely regulated by histone modification.This review systematically explores the specific molecular mechanisms by which key modifications such as histone citrullination,acetylation,and methylation regulate NETosis in ARDS.The cross-dialogue among different modifications and their interactions in the ARDS inflammatory network is explored,and the translational prospects and challenges of targeting histone modifier-NETosis pathways represented by PAD4 inhibitors for ARDS treatment are explored,aiming to provide new ideas and a theoretical basis for future research.