基于"虚气留滞"理论探讨线粒体自噬对缺血性脑卒中的调控机制OA

Ischemic stroke(IS)is a common cerebrovascular disease with a complex pathogenesis and a prolonged,refractory clinical course.Under the guidance of the traditional Chinese medicine theory of"Qi Deficiency and Stasis,"IS can be characterized as a syndrome of deficiency in origin and excess in manifestation,with"Qi Deficiency"as the root and"Stasis"as the manifestation.Recent research has demonstrated the extensive involvement of mitophagy,as a key process in maintaining cellular homeostasis,in the regulation of IS.Its functional state aligns with the pathological changes described in the"Qi Deficiency and Stasis"theory.This review systematically explores the intrinsic relationship between the"Qi Deficiency and Stasis"theory and mitophagy in the occurrence and progression of IS,while proposing therapeutic strategies.By establishing a bridge between traditional Chinese medicine pathogenesis and modern biological mechanisms,it provides a new theoretical basis and research direction for targeting mitophagy in the prevention and treatment of IS based on the"Qi Deficiency and Stasis"theory.