非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比率与脑卒中风险之间的关联OA

[Objective]The aim of this study was to assess the association between NHHR and stroke risk in adults.[Method]A total of 28 827 adult participants from the National Health and Nutrition Examination Survey(NHANES)from 2003 to 2018 were selected for the study.The association between NHHR and stroke risk was explored by multifactorial logistic regression modeling,restricted cubic spline,subgroup and sensitivity analyses.[Result]A total of 28 827 participants were included,of whom 1 091(3.79%)reported a history of stroke.Multifactorial logistic regression showed a 42%reduction in stroke risk in participants in the highest quartile compared with the lowest quartile of NHHR(OR=0.58,95%CI:0.40-0.86,P=0.006).Restricted cubic spline results showed an overall significant association between NHHR and stroke risk(P for overall<0.001)and a significant nonlinear relationship(P for non-linearity<0.001).Subgroup analyses showed that the association between NHHR and stroke risk was more significant(P<0.05)for those with college or higher educa-tion,married,regular physical activity,and no diabetes mellitus.For participants below the inflection point,for every one-unit increase in NHHR,stroke risk decreased by 40%.[Conclusion]NHHR levels showed a nonlinear association with stroke risk,suggesting that NHHR may play a unique role in cerebrovascular risk stratification and early warning.