硒对氧化脂质生物合成的调节及其机理OA
The regulation of selenium on oxylipids biosynthesis and its mechanism
炎症反应异常通常表现为炎症消退延迟或失败,进而发展为低程度的慢性炎症,是许多感染性和代谢性疾病发生的病理原因之一.硒是人和动物的必需微量元素,主要通过合成硒蛋白发挥抗氧化、抗炎、抗病毒、生殖调控等生物学功能.硒可调控氧化脂质的生物合成,而氧化脂质是一类以多不饱和脂肪酸为底物通过酶(环氧合酶、脂氧合酶、细胞色素P450)和非酶(活性氧)代谢途径生成的活性脂质,对炎症的启动、发展和消退起着重要的调节作用.因此,了解硒对氧化脂质生物合成的调节对于阐明硒的抗炎机理具有重要的意义.本文主要从抗氧化调节、氧化还原调节和反馈调节三个方面详细阐述硒对氧化脂质生物合成的调控.
Dysfunctional inflammatory response is usually manifested as delayed or failed inflammation resolution,and then develops into chronic inflammation of low degree,which is the pathological cause of many infectious and metabolic diseases.Selenium is an essential nutrient in the mammalian diet that performs various biological functions including antioxidant,anti-inflammation,antiviral and reproductive regulation mainly in the form of selenoprotein.Selenium can affect the biosynthesis of oxylipins.Oxylipins are a class of bioactive lipids generated from polyunsaturated fatty acids through enzymatic(cyclooxygenase,lipoxygenase,cytochrome P450)and non-enzymatic(reactive oxygen species)metabolic pathways.They play an important role in the initiation,development and regression of inflammation.Understanding the regulation of selenium on the biosynthesis of oxylipins with pro-or anti-inflammatory role is very important to clarify the anti-inflammatory mechanism of selenium.Therefore,this review described in detail the regulation of selenium on oxylipins biosynthesis in three pathways:antioxidant-dependent regulation,redox regulation and feedback regulation.
张盼;王剑秋;崔双;晓敏;弓剑
内蒙古师范大学生命科学与技术学院,内蒙古呼和浩特 01002内蒙古师范大学生命科学与技术学院,内蒙古呼和浩特 01002内蒙古师范大学生命科学与技术学院,内蒙古呼和浩特 01002内蒙古师范大学生命科学与技术学院,内蒙古呼和浩特 01002内蒙古师范大学生命科学与技术学院,内蒙古呼和浩特 01002
农业科技
硒硒蛋白氧化脂质炎症调节
seleniumselenoproteinoxylipinsinflammationregulating effect
《中国饲料》 2026 (11)
7-12,6
国家自然科学基金项目(31960670)内蒙古自然科学基金项目(2025MS03142)内蒙古师范大学自主科研项目(KJJY2X2026075)
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