微小RNA在溃疡性结肠炎中的作用及中药干预研究进展OA

Ulcerative colitis(UC)is a chronic nonspecific inflammatory bowel disease with a long course,easy recurrence,difficult treatment,and a risk of cancer crisis.So far,its pathogenesis remains unclear.MicroRNA(miRNA),a class of non-coding RNA,has been recognized as important regulators of gene expression.Studies have shown that miRNA exhibits differential expression in UC and targets miRNA to participate in post-transcriptional gene expression regulation in UC,mainly regulating intestinal epithelial barrier function,immune homeostasis and inflammatory balance in UC.Therefore,miRNA-based drugs are expected to be potential innovative drugs for UC.Traditional Chinese Medicine(TCM)boasts a broad spectrum of applications for the prevention and treatment of UC,offering significant efficacy and unique advantages such as multi-targeting and multi-pathway effects.However,there is still a lack of review on regulating miRNA by TCM to prevent UC.This article reviewed the mechanisms of miRNA in UC and the research findings on TCM compounds and active components'intervention in miRNA regulation for UC treatment.It was found that TCM could modulate the differential expression of miRNA thereby participating in the regulation of various pathological and physiological processes such as intestinal epithelial barrier damage,apoptosis,inflammation,and abnormal differentiation of immune cells.This modulation contributed to alleviate UC.This review is expected to provide theoretical reference and research guidance for future studies on regulating miRNA therapy for UC.