儿童抗菌药物离院科普框架的构建OA

Background The problem of irrational use of antibacterial drugs by the parents of children after leaving the hospital was particularly prominent.Providing correct guidance and popular science education on the use of antibacterial drugs and to children and their parents was an important measure to improve parents'awareness of antibacterial drugs and the level of their rational use.However,there is currently no standardized scientific popularization framework for the production of resources on antibacterial drugs for children.Objective Formulate a scientific popularization framework for antibacterial drugs for children discharged from hospital,providing a reference for the standardized production of pediatric antibacterial scientific popularization resources and guiding parents to use antibacterial drugs reasonably after discharge.Methods A systematic scoping review of the pediatric antibacterial scientific popularization upon discharge was conducted through literature research,and the content of the literature was integrated by thematic synthesis from December 2024 to February 2025.Based on the results of the review,a preliminary framework was developed and transformed into a questionnaire.Clinical experts engaged in pediatric infections,pediatric scientific popularization,and pediatric medication education were selected.In March 2025,Delphi expert consultation was completed through the questionnaire was distributed and collected via the online platform"Wenjuanxing".Items were considered to have reached consensus if the mean importance score was≥4 and the coefficient of variation(CV)was≤25%.The Delphi expert consultation was used to ultimately determine the indicators and construct a framework for pediatric antibacterial scientific popularization upon discharge.Results A total of 7 886 articles were initially retrieved,and 55 articles were finally included after screening.Thematic synthesis summarized 19 descriptive themes(secondary indicators)and 4 analytical themes(primary indicators).A total of 35 questionnaires were distributed,and 21 were collected.The 21 experts rated the importance of 19 secondary indicators and 4 primary indicators,with all scores ranging from 4 to 5 and CV≤25%.The intraclass correlation coefficient(ICC)was 0.52(95%CI=0.18-0.76,P=0.003),indicating a moderate level of agreement among experts and that consensus was reached.Based on the expert consultation results of the initial indicators,a framework for pediatric antibacterial scientific popularization upon discharge was finally established,including 4 primary indicators(basic knowledge,medication methods,adverse reactions,and behavioral habits)and 19 secondary indicators(definitions of antibiotics,classification of antibiotics,concept differentiation,disease awareness,etc.).Conclusion The framework for pediatric antibacterial scientific popularization upon discharge constructed in this study has high scientific validity and reliability.It can provide an important reference for formulating scientific popularization materials on pediatric antibacterial drugs upon discharge,and guiding parents to use antibacterial drugs reasonably.