重症监护病房一起疑似按蚊伊丽莎白菌医院感染暴发事件的调查与控制OA

Objective To investigate and control a suspected outbreak of Elizabethkingia anophelis(E.anophelis)healthcare-associated infection(HAI)in the intensive care unit(ICU)of a hospital,and to provide evidence for clinical prevention and control.Methods From March 23 to April 1,2025,an epidemiological investi-gation was carried out on 5 patients who were confirmed to be infected with E.anophelis in the hospital.Environ-mental specimens were collected for pathogenic detection,and the homology of strains was analyzed by pulsed-field gel electrophoresis(PFGE).Intervention measures were implemented in different stages,initial measures were contact isolation and strengthened environmental disinfection,followed by deep cleaning of hand-washing sinks,and fluorescence-labelled method was adopted for supervising the quality of cleaning and disinfection.Results All 5 patients received endotracheal intubation or central venous catheterization,with the cases concentrated in zones B/C of the ICU.The detection rate of pathogens from environmental specimens was 2.38%(1/42),and positive speci-men came from hand-washing sink of bed 24.This isolate belonged to the type PFGE-B along with P1 and P2 strains,while P4 and P5 strains belonged to the type A.The P3 strain belonged to type C,indicating the presence of polyclonal transmission.All strains were resistant to β-lactams and aminoglycosides,but sensitive to minocycline and levoflo-xacin.After one-week intervention measures,there were no new cases and the environmental sampling results turned negative.Conclusion The colonization of bacterial strain in the hand-washing sink environment may be the main cause of the suspected E.anophelis HAI outbreak.The combination of molecular typing tracing,targeted intervention,and process supervision can help to control such event.It is recommended to include water-related facilities in the ICU into routine monitoring.