CD34+细胞在心血管疾病中作用机制及治疗应用的研究进展OA

Cardiovascular diseases represent a significant threat to human health globally.With in-depth re-search in stem cells and regenerative medicine,the application of bone marrow transplantation and cell therapy in cardio-vascular diseases is becoming increasingly widespread.Among these,CD34+cells have emerged as critical therapeutic agents due to their multipotent differentiation capabilities.These cells contribute to cardiac remodeling,vascular regenera-tion,and the mitigation of ischemia and fibrosis associated with cardiovascular pathologies through diverse mechanisms,suggesting their potential clinical relevance across a range of cardiovascular disorders.Nonetheless,clinical trial out-comes have been inconsistent,with some studies reporting adverse effects such as aberrant inflammatory responses and pathological endothelial proliferation following CD34+cell therapy,thereby generating considerable debate regarding their therapeutic efficacy.The advent of single-cell RNA sequencing technology has revealed that CD34+cells constitute a het-erogeneous population,comprising tissue-resident and hematopoietic subsets.Depending on specific microenvironmental cues or induction conditions,CD34+cells can differentiate into various cell types,including endothelial cells,inflammato-ry cells,and fibroblasts,each fulfilling distinct functional roles.Therefore,in this review,we will summarize the origins and functions of CD34+cells and explore their differentiation and functional mechanisms in peripheral vascular diseases,aortic vascular diseases,and various cardiac diseases.