烟雾综合征患者脑血流低灌注对认知功能的影响OA

Objective To investigate the clinical and radiological features of patients with moyamoya syndrome(MMS)and the influence of cerebral hypoperfusion on cognitive function in MMS.Methods A total of 153 patients with MMS who were consecutively admitted to Henan Provincial People's Hospital from June 2023 to December 2024 were enrolled,and according to the presence or absence of cognitive impairment,they were divided into cognitive impair-ment group with 73 patients and normal cognitive function group with 80 patients.The two groups were compared in terms of clinical data,cranial MRI data,and perfusion-weighted magnetic resonance imaging(PWI-MRI)data,and the Logistic regression analysis was used to investigate the influencing factors for cognitive impairment in MMS patients.Results Based on the results of Montreal Cognitive Assessment(MoCA)and Mini-Mental State Examination(MMSE),the incidence rate of cognitive impairment in MMS patients was 47.71%(73/153).PWI-MRI showed that in the cognitive impairment group,the patients with local cerebral hypoperfusion(a reduction in relative blood volume)ac-counted for 49.32%(36/73),while in the normal cognitive function,the patients with local hypoperfusion accounted for 31.25%(25/80),and there was a significant difference between the two groups(χ2=5.196,P<0.05).Frontal hypo-perfusion(OR=2.098,95%CI 1.049‒4.196,P=0.036)was a risk factor for cognitive impairment in MMS patients.Conclusion Cognitive impairment is common in MMS patients,and MMS patients with frontal hypoperfusion are more likely to develop cognitive impairment.