基于元分析方法探索轻度认知障碍患者脑灰质结构异常改变OA

Objective Voxel-based morphometry(VBM)has been used to study gray matter volume(GMV)changes in patients with mild cognitive impairment(MCI),but with great differences in current research findings.This study aims to investigate the brain regions showing the most consistently reported GMV differences between MCI patients and healthy controls through a meta-analysis.Methods CNKI,Wanfang Data,Embase,PubMed,and Web of Science were searched for articles on the difference in GMV between MCI patients and healthy controls based on VBM published over the past 10 years,and the articles were screened based on inclusion and exclusion criteria.Signed differential map-ping software was used to compare the difference in GMV between MCI patients and healthy controls.Results A total of 13 studies were included,involving 506 MCI patients and 435 healthy controls.Compared with the healthy control group,the MCI group had a significant reduction in GMV in the right superior temporal gyrus,the left postcentral gyrus,the left putamen,the left medial superior frontal gyrus,the left fusiform gyrus,and the bilateral hippocampus(P<0.005,peak height Z>1,cluster range≥10 voxels).Conclusion The meta-analysis confirmed the most relevant core brain structural regions in MCI patients.These findings not only provide a potential biomarker for MCI,but also help to gain a better un-derstanding of its neuropathological basis.