总抗氧化能力与癌症患者死亡风险的关联分析-基于NHANES数据库回顾性队列研究OA

Objective To explore the association between total antioxidant capacity(TAC)and all-cause mortality among cancer patients.Methods Data from the National Health and Nutrition Examination Survey(NHANES)from 2003 to 2018 were integrated.Logistic regression models were used to assess the association between TAC and clinical outcomes of cancer patients.Cox proportional hazards model was used to analyze the association between TAC quartiles and the risk of all-cause mortality.Kaplan-Meier method was adopted for survival analysis.Results A total of 3171 cancer patients were en-rolled in this study.It was found that cancer was correlated with all-cause mortality(P＜0.0001).Multivariate logistic re-gression analysis revealed that after adjusting for confounding factors,participants in the third TAC quartile(Q3 group)had a lower risk of all-cause mortality than those in the lowest quartile(Q1 group)(HR=0.76,95%CI:0.59～0.98,P=0.037).For breast cancer patients,higher dietary TAC intake was associated with reduced all-cause mortality(Q2 group vs.Q1 group:HR=0.44,95%CI=0.24～0.81,P=0.008;Q3 group vs.Q4 group:HR=0.48,95%CI=0.26～0.89,P=0.021).Subgroup analysis demonstrated that cancer patients who were married or cohabiting presented a lower risk of all-cause mortality,with a significant interaction effect(P=0.036).Kaplan-Meier survival curves showed that the group with high TAC levels had better overall survival than the low TAC group(P＜0.0001).Conclusion Within a certain range,ele-vated TAC levels are correlated with decreased all-cause mortality in cancer patients.Marital and cohabitation status serves as a critical factor moderating the influence of TAC on all-cause mortality.