不同病原肺炎患儿的CRP、IL-6和SAA表达差异分析OA

Objective To compare the differences in the expression levels of C-reactive protein(CRP),interleukin-6(IL-6),and serum amyloid A(SAA)among children with pneumonia caused by different pathogens,and to analyze the associations between these three indicators and different pathogen types.Methods A total of 160 hospitalized children with pneumonia admitted to Kaifeng Children's Hospital from January 2023 to July 2025 were retrospectively enrolled.According to etiology,they were divided into a bacterial group,a viral group,a Mycoplasma group,and a mixed infection group.The general clinical data of the four groups were collected and compared.CRP,IL-6,and SAA were measured within 24 h after admission.Differences in these indicators among the groups were compared.Using the bacterial group as the reference category,multinomial Logistic regression analysis was performed to investigate the associations of CRP,IL-6,and SAA with pneumonia caused by different pathogen types.Results There were no statistically significant differences in general data among the four groups(P＞0.05).The levels of CRP,IL-6,and SAA in the bacterial group were significantly higher than those in the other three groups,followed by the mixed infection group,the Mycoplasma group,and the viral group,which had the lowest levels(P＜0.05).Multinomial Logistic regression analysis showed that,with the bacterial group as the reference category,the levels of CRP,IL-6,and SAA were significantly lower in the viral group,Mycoplasma group,and mixed infection group(P＜0.05).Further analysis suggested that decreases in CRP,IL-6,and SAA levels were associated with an increased likelihood of being classified into the viral group,Mycoplasma group,or mixed infection group rather than the bacterial group.Conclusion CRP,IL-6,and SAA can effectively reflect the intensity of inflammatory responses in children with pneumonia caused by different pathogens and are closely associated with pathogen classification,with the most pronounced inflammatory response observed in children with bacterial infection.